One of the great officers of state under King Amenhotep II, Maanakhtef was responsible for the direction of Egypt's agricultural production and the overall control of the royal estates. A fine cube statue of Maanakhtef, now in the Louvre, was found in the excavations of the temple at Medamud.

His titles included Grand Intendent and Royal Chamberlain, Master of the Double Granary, and Master of the Peasants and Serfs of the King; his duties were perhaps equivalent to those of a Minister of Agriculture.